Conn syndrome is related to autonomous aldosterone production causing sodium retention, plasma renin suppression, hypertension, cardiovascular damage, and increased potassium excretion, leading to variable degrees of hypokalemia ( 8). The clinical manifestations of CS are related to the patient’s age and the duration and degree of the hypercortisolism ( 5).Ĭonn syndrome, or primary aldosteronism, which is characterized by excessive spontaneous secretion of aldosterone from the adrenal glands, affects 6% of people with high blood pressure and can be either sporadic or familial ( 6, 7). CS is most commonly caused by adrenal adenomas other causes include adrenocortical carcinoma (ACC), pheochromocytomas.ĬS is characterized by symptoms such as central obesity, buffalo hump, a rounded face, chromatosis, muscle weakness, hypertension, acne, hirsutism, menstrual irregularities, diabetes mellitus, osteoporosis, immune suppression, gonadal dysfunction, and mood changes ( 1- 3, 5). Females are more likely to have CS than males.

The triggering pathways of CS can be divided into pituitary-dependent and pituitary-independent. CS can result from exogenous administration of glucocorticoids or endogenous overproduction of cortisol ( 4). Table 2 The causes of Conn syndrome and Cushing syndrome in adrenal glandsĬS or hypercortisolism is classically described as the signs and symptoms associated with prolonged exposure to pathologically elevated cortisol levels ( 2), which represents hypercortisolism stemming from various causes other than a pituitary adenoma ( 3). Policy of Dealing with Allegations of Research Misconduct.Policy of Screening for Plagiarism Process.

Adrenal gland pain location